ea0019p319 | Steroids | SFEBES2009
Michaelis M
, Hofmann P
, Goetz F
, Kienitz T
, Quinkler M
Introduction: 11β-HSD1 is the key enzyme of intracellular glucocorticoid regulation by converting inactive cortisone to active cortisol. The latter binds to the glucocorticoid and mineralocorticoid receptor (MR) in the heart. Cortisol excess in Cushings syndrome leads to left ventricular hypertrophy. Also androgens cause myocardial remodelling. However, the impact of testosterone on the cardiovascular system is strongly disputed showing beneficial and deleterious ef...